There's not a distinct run like you see with suckers (btw, the smallmouth & black buffalo run is on right NOW!). Spawning aggregations seem to be more fleeting and spread over a longer period in early summer than some studies would suggest.
Sambolie nailed the best pattern -- fish larger rivers like you were fishing for smallmouth. Sight fishing for them can be extremely challenging on fly. I've got a couple good options for that, but would prefer discussing that over PM...
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